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KMID : 0363619990200030036
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 3 p.36 ~ p.44
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Role of Posterior Intralaminar Thalamic Nuclei in Acupuncture Analgesia in Rats
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Ro Shick
woon Sang-Hyub
Min Byung-Il
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Abstract
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Objectives: It has been well known that electroacupuncture(EA) has an analgesic effect and there is a pain control system in the central nervous system(CNS). The pain control system is composed of three major nuclei, which are periaqueductal gray(PAG), raphe nuclei, and the pain inhibitory complex located in the spinal cord. It has been suggested that the analgesic effect of EA might be the result of activation of the pain control system in the CNS. However, there may be a possibility that other nuclei are also involved in this pain modulation. Thus, we investigated whether the posterior intralaminar thalamic nuclei (PTIN) are involved in the pain modulation.
Methods: To measure the level of pain, the jaw opening reflex (JOR) was used as a pain index. The magnitude of JOR is estimated by averaging the area of 10 successive responses. JOR was evoked by tooth-pulp stimulation with bipolar electrode carrying stimulus with the following parameters: intensity ranging from 420uA to 680ulA, 0.3ms duration of square pulse, and 0.5 Hz. Hapkog(LI_4) and Taechung (LR_3) were the chosen acupoints. The Hapkog point was stimulated ipsilaterally at 5V, 3 Hz, for 15min in total, and the Taechung was stimulated at 2-3 V, 3 Hz, and for a total of 15 or 30 minutes. Different intensities of stimulation were given the PITN; one was given at 300{mu}A and the other was at 500uA. The position stimulated in these nuclei by Paxinos Atlas was AP; from bregma -4.0{sim}-4.3mm,;L; 0.5{sim}1.8mm,;D;;4.8{sim}6.3mm.
Results: The Hapkog point had a significant analgesic effect (P<0.05). However, the Taechung point had no effect. Both types of stimulation in the PITN did not reveal any analgesic effects.
Conclusions: From these results, it was suggested that the posterior intralaminar thalamic nuclei are not involved in the modulation of pain.
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KEYWORD
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electroacupuncture, hapkog(LI_4), taechung(LR_3), acupoint, posterior intralaminar nuclei, jaw opening reflex
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